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In previous studies that explored the influence of cytokines on foreign body giant cell (FBGC) formation, we focused on interleukin (IL)−4 and IL‐13, each of which was discovered to induce macrophage fusion leading to FBGC formation in vitro. Two correlative in vivo studies also confirmed that IL‐4 plays a role in FBGC formation on implanted biomaterials, but that T lymphocytes are not the source...
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