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This paper presents a new procedure to find the impact of the time-delay (TD) of the patient and instrumentations such as bispectral index (BIS) monitor on closed-loop control of depth of anaesthesia during surgery. In the current work, the TD is estimated using Smith Predictive control technique. The method is validated with measured BIS signals in simulation. The results showed that the proposed...
This paper is a comprehensive literature review on the Depth of Anaesthesia (DoA) monitoring problem. We first investigate the current clinical practice, then briefly introduce the DoA monitors, finally we analyse and discuss the reliability and accuracy of current DoA assessment practice. In this study we find that most of the responses suppressed by anaestheic agents are not of the central nervous...
The manual control of anaesthesia is still the dominant practice during surgery. An increasing number of studies have been conducted to explore the possibility of automating this process. The major difficulty in the design of closed-loop control during anaesthesia is the inherent patient variability due to differences in demographic and drug tolerance. These discrepancies are translated into the differences...
The major difficulty in the design of closed-loop control during anaesthesia is the inherent patient variability due to differences in demographic and drug tolerance. These discrepancies are translated into the pharmacokinetics (PK), and pharmacodynamics (PD). These uncertainties may affect the stability of the closed loop control system. This paper aims at developing predictive controllers using...
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