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Coronary heart disease is now a severe burden on society and family in both industrialized and developing countries, but the traditional related factors can not explain the whole situations. The effect of treatment is very limited. Determination of treatment based on the symptoms and signs in Traditional Chinese Medicine (TCM) have certain curative effect. But the objective of the syndrome diagnose...
We describe a new approach for inferring the functional relationships between non-homologous protein families by looking at statistical enrichment of alternative function predictions in classification hierarchies such as Gene Ontology (GO) and Structural Classification of Proteins (SCOP). Protein structures are represented by robust graphs, and the Fast Frequent Subgraph Mining algorithm is applied...
The problem of selecting a sample subset sufficient to preserve diversity arises in many applications. One example is in the design of recombinant inbred lines (RIL) for genetic association studies. In this context, genetic diversity is measured by how many alleles are retained in the resulting inbred strains. RIL panels that are derived from more than two parental strains, such as the collaborative...
We present a novel application of graph database mining to identify tertiary motifs in RNA structures. In our method, we abstract an RNA molecule as a labeled graph and use a frequent subgraph mining technique to derive tertiary motifs. By applying our technique to ribosome RNA and transfer RNA, we have identified known RNA tertiary motifs such as the ribose zipper and U-turn, plus candidates for...
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