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Cyclotide sind pflanzliche Mikroproteine mit zirkularer Cys‐Knotentopologie. J. A. Camarero et al. zeigen in der Zuschrift auf S. 8510 ff. die heterologe Expression von Cyclotiden innerhalb lebender Hefezellen. Dieser Ansatz wurde zur Produktion eines Cyclotids verwendet, das α‐syn‐induzierte Zytotoxizität in einem Synucleopathiemodell inhibiert.
We report for the first time the recombinant expression of fully folded bioactive cyclotides inside live yeast cells by using intracellular protein trans‐splicing in combination with a highly efficient split‐intein. This approach was successfully used to produce the naturally occurring cyclotide MCoTI‐I and the engineered bioactive cyclotide MCoCP4. Cyclotide MCoCP4 was shown to reduce the toxicity...
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