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1. In rat aortic rings contracted by phenylephrine, acetylcholine relaxation was partly inhibited by: iberiotoxin, a Ca 2+ -activated K(K Ca ) channel inhibitor; glyburide, an ATP-dependent K(K ATP ) channel inhibitor; and 4-aminopyridine, a voltage-dependent K(K V ) channel inhibitor, and was almost abolished by the removal of endothelium.2. N ...
1. 1. In rat aortic rings precontracted by phenylephrine, H7 (10 −5 M) and staurosporine (10 −7 M), which inhibit PKA, PKG and PKC, and H-89 (10 −6 M), which inhibits PKA and PKG, potentiated relaxations induced by nitroglycerin. Forskolin-induced relaxations were not affected by H7 (10 −5 M). 2. 2. Nitroglycerin-induced relaxations were not affected by calphostin-C...
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