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Background Immunotherapeutic treatments targeting amyloid-β plaques in Alzheimer’s disease (AD) are associated with the presence of amyloid-related imaging abnormalities with oedema or effusion (ARIA-E), whose detection and classification is crucial to evaluate subjects enrolled in clinical trials. Purpose To investigate the applicability of subtraction MRI in the ARIA-E detection using an established...
INTRODUCTION
Immunotherapeutic agents against amyloid beta (Aβ) are associated with adverse events, including amyloid‐related imaging abnormalities with edema and effusion (ARIA‐E). Recently, a magnetic resonance imaging (MRI) rating scale was developed for ARIA‐E detection and classification. The aim of this study was to validate the use of this rating scale in a larger patient group with multiple...
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