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Water-soluble components from pollen modulate dendritic cell (DC) functions, such as IL-12 secretion and 3′-5′-cyclic adenosine monophosphate (cAMP) signaling and migration, possibly contributing to the establishment of a T H 2-dominated immune response against pollen. Because these effects could not solely be attributed to the previously identified pollen-associated lipid mediators, the pollen...
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