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Since the early concepts on the importance of the phagocyte in the host defense and inflammation as introduced by Metnivos more than 100 years ago (for which he was awarded the Nobel prize) the focus of research in inflammation was maintained with the credo — elucidate the chemical mediators that could cause/mediate the cardinal signs of inflammation — heat, redness, swelling, pain and loss of function...
Resolution of inflammation is an active, highly regulated process that is already encoded at the onset and is required to prevent the transition into chronic inflammation associated with spreading of tissue injury, exacerbated scarring, and pain. In this chapter, we introduce the concept of resolution of inflammation in central nervous system (CNS) lesions and summarize emerging evidence for the bioactivity...
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