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The purpose of this study is to evaluate the effects of dexamethasone on mesenchymal stem cells from human gingiva using next-generation sequencing. The verification and suggestion of possible mechanisms was performed. Human gingiva-derived stem cells were treated with a final concentration of 10-7M dexamethasone at 2 and 24 hours. Extraction of RNA, sequencing of mRNA, gene ontology and pathway analysis...
Objectives To evaluate the effects of dexamethasone on the aging of mesenchymal stem cells from human gingiva using next-generation sequencing. Results Four mRNAs were upregulated and 12 were downregulated when the results of dexamethasone at 24 h were compared with the control at 24 h. Expressions of SIRT1 and IL6 were decreased in dexamethasone at 24 h but expression of EDN1 was increased. Conclusions...
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