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Background
Allergen immunotherapy has been shown to be an effective treatment for local allergic rhinitis (LAR) to house dust mites. Studies with pollen allergen immunotherapy are limited to observational studies. The aim of this study was to evaluate the clinical efficacy and safety of Phleum pratense subcutaneous immunotherapy (Phl‐SCIT) in LAR.
Methods
In a randomized double‐blind placebo‐controlled...
In the past years, several investigators have demonstrated the existence of local nasal responses in some patients with typical allergic rhinitis symptoms but without atopy and have defined a new phenotype called local allergic rhinitis (LAR) or ‘entopy’. In a percentage of LAR subjects, the upper airway disease is also associated with lower airway symptoms. After the description of this phenotype,...
The effects of allergen immunotherapy (AIT) on local allergic rhinitis (LAR) are largely unknown. We conducted the first randomized, double‐blind, placebo‐controlled (DBPC), phase II trial of D. pteronyssinus (DP) subcutaneous AIT (DP‐AIT) on LAR (clinicaltrials.gov identifier: NCT02123316). Thirty‐six LAR patients received Pangramin PLUS DP or placebo for 24 months. The primary endpoints were symptoms,...
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