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Caseinolytic protease P (ClpP) is the proteolytic component of the ClpXP protein degradation complex. Eukaryotic ClpP was recently found to act within the mitochondria‐specific unfolded protein response (UPRmt). However, its detailed function and dedicated regulation remain largely unexplored. A small molecule (D9) acts as a potent and species‐selective activator of human ClpP (hClpP) by mimicking...
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