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27‐Hydroxycholesterol (27HC) is a purported, novel endogenous SERM. In animal models, 27HC has an anti‐estrogen effect in bone, and 17β‐estradiol mitigates this effect. 27HC in relation to fracture risk has not been investigated in humans. Depending on the level of bioavailable 17β‐estradiol (bioE2), 27HC may increase fracture risk in postmenopausal women and modify the fracture risk reduction from...
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