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Background
Azoospermia factor C (AZFc) in the male‐specific region of Y‐chromosome (MSY) presents wide structure variation mainly due to frequent non‐allele homologous recombination, leading to significant copy number variation of the AZFc‐linked coding sequences involving in spermatogenesis. A large number of studies had been conducted to investigate the association between AZFc deletions and male...
Background
Numerous studies have been performed to investigate the association between the primary AZFc duplication and male infertility risk; however, the sample sizes have been small and the results have been controversial. A meta‐analysis was performed to assess these associations.
Methods
A systematic search was conducted to identify all relevant studies from the PubMed, Web of Science, Medline,...
Background
Metformin, a drug used to treat type 2 diabetes, has gained attention for its multiple therapeutic applications. However, little is known about its effects on human sperm function at therapeutically relevant concentration.
Objectives
The aim of this study was to elucidate the in vitro actions of metformin on human sperm function and explore the underlying mechanism of any effects.
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