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A mathematical model describing the relationship between uninfected hepatocytes, infected hepatocytes, HBV, CD8+ T-cells(CTL), antigen presenting cells, CD4+ T cells (Th1 and Th2), plasma cells, antibody, and so on was established to explain the mechanism of HBV infection. The mathematical analysis result shows the condition of how can the immune system eliminate HBV entirely from the body. The model...
A mathematical model describing the immune response to HBV infection was established. The immune reaction effect included both humoral and cellular immune response. Why the immune system failed to eliminate the virus was explained by the equilibrium state analysis result that the immune response was not strong enough to resolve the HBV infection. Simulations were made to show the wide variety of clinical...
Nowak's model of the human immunodeficiency virus (HIV) infection has been extensively and successfully used to simulate the interaction between HIV and cytotoxic lymphocyte (CTL)-mediated immune response. However, such model is not available for hepatitis B virus (HBV). As the enhanced recruitment of virus-specific CTLs into the liver has been an important novel concept in the pathogenesis of hepatitis...
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