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Osteoporotic fractures cause major morbidity and mortality in the aging population. Genome‐wide association studies (GWAS) have identified USF3 as the novel susceptibility gene of osteoporosis. However, the functional role in bone metabolism and the target gene of the basic helix‐loop‐helix transcription factor USF3 are unclear. Here, we show that USF3 enhances osteoblast differentiation and suppresses...
Upstream transcription factor family member 3 (USF3) c.3781C>A (rs1026364) in the 3′‐untranslated region (3′‐UTR) has been firmly associated with bone mineral density (BMD) in genome‐wide association study (GWAS). However, the molecular mechanism by which it influences BMD and osteoporosis is unknown. Bioinformatics analyses suggested that the risk c.3781A allele creates a target site for hsa‐miR‐345‐5p...
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