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This paper presents a programmable lab-on-CMOS (LoCMOS) with micro-electrode cell array. Array structure is suitable for programmable like CMOS VLSIs. In order to improve the utilization, each micro-electrode cell is composed of actuation and sensing circuit. In addition, a CMOS-compatible extended drain MOSFET (EDMOS) is adopted under a 3V supply. This LoCMOS platform is composed of 1,800 microelectrodes...
This paper presents a field programmable lab-on-a-chip (FPLOC) with microfluidics actuation, droplet location/ category readback, built-in-self-test (BIST), and bioassays detection. This FPLOC is composed of 1,800 MEDA microelectrodes and integrates a set of microfluidic operations to perform droplet moving/cutting/mixing. Besides, capacitive sensing circuits are considered for system automation,...
A digital microfluidic processor for biomedical detection is presented. This processor integrates the functions of droplet actuation, droplet position/shape/ volume detection and capacitive measurement window to demonstrate a novel prototype for personalize medicine. In this proposed system, the location map of micro droplets and reaction behaviors are visible on 2-dimentional (2D) graphical user-interface...
Single nucleotide polymorphism (SNP) detection is one of the most critical genomic technologies. The SNP detection techniques today mostly utilized fluorescent dye labeled DNA probe or molecular beacon, which need high reagent cost. In this research, a genotyping system is developed by integrating miniaturized the dynamic allele-specific hybridization (DASH) technique with a bead-based microfluidic...
A methodology characterizing the strength of PDMS bonding has been proposed. This method employs a blister test to measure and a line force model to describe the bonding strength. The blister test provides us a close approximation to the bonding failure modes under field-used situations. The line force model is a general means to study the bonding strength. A series of the blister tests on PDMS samples...
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