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Background Alternative polyadenylation (APA) results in messenger RNA molecules with different 3′ untranslated regions (3’ UTRs), affecting the molecules’ stability, localization, and translation. APA is pervasive and implicated in cancer. Earlier reports on APA focused on 3’ UTR length modifications and commonly characterized APA events as 3’ UTR shortening or lengthening. However, such characterization...
Multi-disciplinary virtual prototype (MDVP) based on modeling and computer simulation technology has been applied in a wide range of engineering applications, especially the design, testing and evaluation of complex products. Generally, a large set of parameters need to be optimized to improve the performance of the prototype, which comprises a number of heterogeneous models from multiple domains...
With the more and more serious population aging problem, the demand of long-term care is increasing. Actually, most of the aging people have the ability to take care of themselves, some warm concerns, medical advices, and timely remainders can effectively improve their living quality. Therefore, an automatic system to track and record elderly people's daily life and activities is required. In this...
Cloud Manufacturing can provide mass manufacturing resources and capabilities as services via the Internet. Undoubtedly, multiple manufacturing clouds (MCs) will have extremely abundant services in terms of function, price, etc. The ability to leverage ample services hosted in MCs has direct relation to the success or failure of a manufacturer. Meanwhile, various uncertainties in today's highly-dynamic...
The Internet of Things (IoT) envisions the seamless interconnection of the physical world and the cyber space. This provides a promising opportunity to build powerful services and applications for manufacturing. This paper provides an overview of key research issues to be addressed and the latest advances in the area of IoT-enabled manufacturing. We first introduce the core technologies of IoT, such...
Cloud Manufacturing (CMfg) adopts and extends the concept of cloud computing to make mass Manufacturing Resources and Capabilities (MR/Cs) more widely integrated and accessible to users through the Internet. However, a single manufacturing cloud (MC) only has relatively limited scalability and elasticity. Using the aggregated MR/Cs from multiple MCs is a natural evolution. To address this requirement,...
RFID technology is the popular technology in recent years and applies to many automatic identification applications such as supply chain management, thief-prevention and so on. Supply chain system with the help of RFID system reduces the cost in business operation. Different members in the supply chain connect to the same RFID tag for acquiring their own data. Members can protect their secret information...
The popularity of the modeling and simulation application increases the demand for acquiring the service of the simulation resource and capability (R/C) anytime, anywhere, on demand through the network. Cloud simulation draws the idea of cloud computing that integrates and shares the R/Cs to provide services which significantly depending on the R/Cs' management. Most existing work assumes that there...
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