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Diagnostics is the key in screening and treatment of cancer. As an emerging tool in precision medicine, metabolic analysis detects end products of pathways, and thus is more distal than proteomic/genetic analysis. However, metabolic analysis is far from ideal in clinical diagnosis due to the sample complexity and metabolite abundance in patient specimens. A further challenge is real‐time and accurate...
In article number 2000906, Mawei Jiang, Kun Qian, and co‐workers report synthetic Pd–Au alloys for mass‐spectrometry‐based metabolic fingerprinting and analysis, toward diagnosis and radiotherapy evaluation of medulloblastoma. Medulloblastoma patients are diagnosed by machine learning, while radiotherapy is monitored and a preliminary panel of serum metabolite biomarkers is identified with gradual...
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