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Noninvasive aerosol inhalation is an established method of drug delivery to the lung, and remains a desirable route for nucleic‐acid‐based therapeutics. In vitro transcribed (IVT) mRNA has broad therapeutic applicability as it permits temporal and dose‐dependent control of encoded protein expression. Inhaled delivery of IVT‐mRNA has not yet been demonstrated and requires development of safe and effective...
In vitro transcribed messenger RNA is nebulized using poly(beta amino esters) for inhalable delivery to the lung as described by Daniel G. Anderson and co‐workers in article number 1805116. Hyperbranched polymers are synthesized, which form stable mRNA‐polyplexes that distribute uniformly throughout the lungs of mice and are translated to reporter protein in the lung epithelium.
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