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Personalized radiotherapy strategies enabled by the construction of hypoxia‐guided biological target volumes (BTVs) can overcome hypoxia‐induced radioresistance by delivering high‐dose radiotherapy to targeted hypoxic areas of the tumor. However, the construction of hypoxia‐guided BTVs is difficult owing to lack of precise visualization of hypoxic areas. This study synthesizes a hypoxia‐responsive...
The human brain and central nervous system (CNS) present unique challenges in drug development for neurological diseases. One major obstacle is the blood–brain barrier (BBB), which hampers the effective delivery of therapeutic molecules into the brain while protecting it from blood‐born neurotoxic substances and maintaining CNS homeostasis. For BBB research, traditional in vitro models rely upon Petri...
Blood–Brain Barrier Models
In article number 2201401, Mehmet Remzi Dokmeci, Ali Khademhosseini, and co‐workers discuss recent progress and key applications of blood–brain barrier (BBB)‐on‐a‐chip and delineate potential future directions.
Highly stretchable, conductive, biocompatible conductors, and connectors are crucial for the fabrication of flexible devices. However, it remains a problem to get highly stretchable, conductive materials with low cost on a large scale. Another problem in production is the connection between soft and rigid components. Here, a new conductive nanocomposite is reported by mixing the 11‐mercaptoundecanoic...
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