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Acoustic droplet vaporization (ADV) is a process when a droplet is converted into a gaseous bubble under ultrasound (US) stimulation. Our previous study has shown that the mechanical force generated by ADV can release drugs and disrupt vessels. It would result in the streaming intact droplets leaking into tissue. In addition, the intact droplets may occur ADV process by subsequent US stimulation....
The major obstacles that limit the success of delivery chemotherapeutic substances in brain tumors is their ability to reach the lesion at necessary doses while minimizing deposition at healthy locations to reduce nonspecific toxicity. Lately, administration of therapeutic substances after blood-brain barrier disruption (BBBD) by microbubbles (MBs) with focused ultrasound (FUS) has been demonstrated...
Ultrasound (US) sonication can vaporize perfluorocarbon droplets into gaseous phase, called acoustic droplet vaporization (ADV). During ADV, the occurring inertial cavitation can burst tumor vessels, improve drug extravasation, and change tumor microenvironments; which provides a potential strategy to simultaneously combine anti-angiogenesis treatment and chemotherapy. Doxorubicin-loaded nanodroplets...
Incomplete data are common problems in longitudinal studies. For incomplete longitudinal binary data, Fitzmaurice et al. (2001) discussed the impact on bias of the different estimating equation approaches where incompleteness follows a MAR (missing at random) process. They pointed out that GEE (generalized estimating equations) method proposed by Liang and Zeger (1986) has manifest bias as MAR drop-out...
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