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Background/Aims
Allopurinol can cause HLA class I‐associated life‐threatening severe skin reactions. However, HLA risk and association with clinical features in allopurinol hepatotoxicity are unknown.
Methods
Eleven of 17 patients with suspected allopurinol hepatotoxicity enrolled into the Drug‐Induced Liver Injury Network were adjudicated as definite, highly likely, or probable. High‐resolution...
Background/aims: Hepatitis B infection is a well‐known cause of hepatocellular carcinoma (HCC). This study aims to investigate the role that the co‐stimulatory molecule CD28 and co‐inhibitory molecule programmed death‐1 (PD‐1) play in compromising the function of tumour‐infiltrating lymphocytes (TIL) in hepatitis B virus (HBV)‐related HCC.
Methods: A total of 45 patients with HBV‐related HCC were...
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