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Etoposide (VP16), an anti-neoplastic agent, exhibits low and variable bioavailability. We have developed and validated a rapid, sensitive, and accurate LC–UV method for the determination of VP16 in vitro and in rat plasma after oral administration. The method was then used to investigate the absorption characteristics of VP16 with an in vitro diffusion chamber system across isolated rat intestinal...
Daidzein (4′,7-dihydroxylisoflavone), a water-insoluble isoflavone, is mainly present in leguminous plants. This study was aimed at investigating the absorption characteristics of daidzein across the intestinal membranes. Borneol has been used to enhance the intestinal absorption and bioavailability of daidzein. We chose an in vitro diffusion chamber system using isolated rat intestinal membranes...
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