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As one of the most promising drug‐delivery carriers due to its small size, easy surface modifiability, and hydrophobic interior, cationic poly(amidoamine) (PAMAM) per se, demonstrated by previous reports and the authors’ present study, indicate potential anticancer capability, however, which are restricted by autophagy elicitation. Besides, its side‐toxicity profile, having also been extensively documented,...
Transcription factor EB (TFEB) is a master regulator of autophagy and lysosomal biogenesis. Here, silver nanoparticles (Ag NPs)‐induced cytoprotective autophagy required TFEB is shown. Ag NPs‐induced nucleus translocation of TFEB through a well‐established mechanism involving dephosphorylation of TFEB at serine‐142 and serine‐211 but independent of both the mTORC1 and ERK1/2 pathways. TFEB nucleus...
Autophagic lysosomal reformation, a key cellular process for maintaining lysosome homeostasis in elevated autophagy, so far has only been reported for cells under certain forms of starvation. For this reason, it is controversial that whether this phenomenon is starvation-specific and its importance in lysosomal regeneration at the late stage of autophagy is often challenged. Here we show that exogenous...
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