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Recent advances in 3D culture systems have led to the generation of brain organoids that resemble different human brain regions; however, a 3D organoid model of the midbrain containing functional midbrain dopaminergic (mDA) neurons has not been reported. We developed a method to differentiate human pluripotent stem cells into a large multicellular organoid-like structure that contains distinct layers...
We give a new sparse penalty for high-dimensional nonparametric additive models and propose an efficient and practical algorithm with concrete expression even when the number of covariates is larger than the sample size. Moreover, some simulation results are illustrated, and we also analyze the theoretical properties and sparse oracle inequalities of the additive models without compatibility condition.
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