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Background and aims
The activity of CYP2A6, the major nicotine‐inactivating enzyme, is measurable in smokers using the nicotine metabolite ratio (NMR; 3′hydroxycotinine/cotinine). Due to its role in nicotine clearance, the NMR is associated with smoking behaviours and response to pharmacotherapies. The NMR is highly heritable (~80%), and on average lower in African Americans (AA) versus whites. We...
Background African Americans are at risk of inadequate adherence to smoking cessation treatment, yet little is known about what leads to treatment discontinuation. Purpose The purpose of this study was to examine the factors associated with discontinuation of treatment in African American light smokers (≤10 cigarettes per day). Methods Bupropion plasma levels and counseling attendance were measured...
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