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Background and aims
Varenicline and nicotine replacement therapy (NRT) are the most commonly used medications to quit smoking. Given their widespread use, monitoring adverse risks remains important. This study aimed to estimate the neuropsychiatric and cardiovascular risks associated with varenicline and NRT as used in routine UK care.
Design
Case–cross‐over study.
Setting
UK‐based electronic...
Aims
To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E.
Design
Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects,...
Aims
To investigate whether smokers prescribed varenicline had lower risks of serious ill‐health during the 4 years following treatment compared with those prescribed nicotine replacement therapy (NRT).
Design
Observational cohort study of electronic medical records.
Setting
A total of 370 UK general practices sampled from the Clinical Practice Research Datalink.
Participants
A total of 126...
Background and aims
Studying the consequences of addictive behaviours is challenging, with understanding causal relationships from observational data being particularly difficult. For example, people who smoke or drink excessively are often systematically different from those who do not, are less likely to participate in research and may misreport their behaviours when they do. Furthermore, the direction...
Aims
To evaluate the utility of coffee‐related genetic variants as proxies for coffee consumption in Mendelian randomization studies, by examining their association with non‐alcoholic beverage consumption (including subtypes of coffee and tea) and a range of socio‐demographic and life‐style factors.
Design
Observational study of the association of genetic risk scores for coffee consumption with...
Background and Aims
Coffee consumption and cigarette smoking are strongly associated, but whether this association is causal remains unclear. We sought to: (1) determine whether coffee consumption influences cigarette smoking causally, (2) estimate the magnitude of any association and (3) explore potential mechanisms.
Design
We used Mendelian randomization (MR) analyses of observational data, using...
AimsTo estimate associations between smoking initiation, smoking persistence and smoking heaviness and caffeine consumption in two population‐based samples from the Netherlands and the United Kingdom.
DesignObservational study employing data on self‐reported smoking behaviour and caffeine consumption.
SettingAdults from the general population in the Netherlands and the United Kingdom.
ParticipantsParticipants...
AimsTo assess whether associations between maternal smoking during pregnancy and offspring smoking initiation are due to intrauterine mechanisms.
DesignComparison of associations of maternal and partner smoking behaviour during pregnancy with offspring smoking initiation using partner smoking as a negative control (n = 6484) and a Mendelian randomization analysis (n = 1020), using a genetic variant...
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