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Areca nut (AN) is an addictive carcinogen used by about 200–600 million people worldwide. Some AN components are shown to induce apoptosis; however, we previously demonstrated that AN extract (ANE) and the 30–100kDa fraction of ANE (ANE 30–100K) induced autophagy-like responses, such as swollen cell morphology, empty cytoplasm, acidic vesicles, and LC3-II accumulation, in an oral cancer cell line,...
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