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In this paper, we present a novel method to study the effect of induced mild hypothermia on cerebral vascular responses. To measure cerebral vascular responses, a minimally invasive imaging method, temporal laser speckle imaging, was developed and adapted for induced-hypothermia rat model. Experiments were carried out in rats under anesthesia. Laser speckle images were acquired at different temperature...
An integrated optical system combining optogenetics and laser speckle contrast imaging (LSCI) method was explored. For the first time, LSCI was demonstrated capable of revealing the modulated neuronal behavior induced by light activated halorhodopsin — a light sensitive chloride pump. Decreased amplitude and extent of both cerebral blood flow response and oxy-hemoglobin concentration response were...
Laser speckle contrast imaging (LSCI) has classically been used to image regional blood flow changes in animal models. In this paper, we demonstrate the use of LSCI for elucidating blood flow characteristics in individual microvessels with diameters as small as 24μm. We extracted profiles of speckle contrast values within individual vessels, both along their diameters and along their lengths and inferred...
Brain's functional response can be studied by observing the spatiotemporal dynamics of functional and structural changes in cerebral vasculature. However, very few studies explore detailed changes at the level of individual microvessels while revealing the simultaneous wide field view of microcirculation responses to functional stimulation. Here we use a high spatiotemporal resolution laser speckle...
A laser speckle imaging (LSI) technique, with high spatio-temporal resolution, is presented for studying cerebrovascular response to stimulation. LSI is evaluated in a rodent model of cerebrovascular activity, in a model of migraine, by eliciting functional response to brain trigeminal nerve stimulation. The specific haemodynamic response, including deoxy-hemoglobin saturation and blood flow responses...
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