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In the mouse and several other species, including man, capacitated acrosome-intact spermatozoa interact with natural [soluble zona pellucida (ZP) and progesterone (P4)] and synthetic [neoglycoproteins (ngps) and calcium (Ca 2+ ) ionophore] agonists, prior to the initiation of a Ca 2+ -dependent signal transduction cascade. The net result is the fusion of the sperm plasma...
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