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The effects of sera from diabetic patients and healthy donors on the synthesis of prostaglandin I 2 (PGI 2 ) and PGI 3 in vitro were studied in confluent bovine aortic endothelial cells cultured with EPA. The products 6-keto-PGF 1α and Δ 17 -6-keto-PGF 1α were measured by GC/SIM as markers of PGI 2 and PGI 3 formation...
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