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The 1 H/ 15 N HSQC NMR spectra of complexes of Lactobacillus casei dihydrofolate reductase containing methotrexate recorded at 1°C show four resolved signals for the four NH η protons of the Arg 57 residue. This is consistent with hindered rotation in the guanidino group resulting from interactions with the α-carboxylate of methotrexate. Increasing the temperature causes...
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