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It has been well‐established that light‐matter interactions, as manifested by diverse linear and nonlinear optical (NLO) processes, are mediated by real and virtual particles, such as electrons, phonons, and excitons. Polarons, often regarded as electrons dressed by phonons, are known to contribute to exotic behaviors of solids, from superconductivity to photocatalysis, while their role in materials’...
How to better understand the influence of electromagnetic parameters on the absorbing properties of electromagnetic wave absorbers (EMAs) is an essential prerequisite for further synthesis and development of high‐performance EMAs. In this work, an improved wave cancellation theory is used as a guiding principle to prepare N‐doped carbon‐coated cobalt nanoparticles (Co@NC) using ZIF‐8@ZIF‐67 as the...
Constructing the adjustable surface conductive networks is an innovation that can achieve a balance between enhanced attenuation and impedance mismatch according to the microwave absorption mechanism. However, the traditional design strategies remain significant challenges in terms of rational selection and controlled growth of conductive components. Herein, a hierarchical construction strategy and...
Single‐Cell Genome Sequencing
In article number 2100325, Chunyu Li, Bo Ma, and co‐workers present an addressable dynamic droplet array (aDDA) that combines the advantages of static droplet arrays and continuous‐flow droplet platforms. All the sample preparation steps including single‐cell isolation, cell lysis, and amplification are performed in sequence within a sub‐nanoliter (≈300 pL) droplet, resulting...
An addressable dynamic droplet array (aDDA) is presented that combines the advantages of static droplet arrays and continuous‐flow droplet platforms. Modular fabrication is employed to create a self‐contained integrated aDDA. All the sample preparation steps, including single‐cell isolation, cell lysis, amplification, and product retrieval, are performed in sequence within a sub‐nanoliter (≈300 pL)...
The unsymmetrical morphology and unique properties of Janus nanoparticles (JNPs) provide superior performances for biomedical applications. In this work, a general and facile strategy is developed to construct a series of symmetrical and unsymmetrical chitosan/gold nanoparticles. Taking advantage of the active motion derived from Janus structure, selective surface functionalization of polysaccharide...
Self‐assembly of gold nanoparticles demonstrates a promising approach to realize enhanced photoacoustic imaging (PAI) and photothermal therapy (PTT) for accurate diagnosis and efficient cancer therapy. Herein, unique photothermal assemblies with tunable patterns of gold nanoparticles (including arcs, rings, ribbons, and vesicles) on poly(lactic‐co‐glycolic acid) (PLGA) spheres are constructed taking...
In article number 2001172, Jian Xu, Bo Ma, and co‐workers invent Raman‐activated gravity‐driven single‐cell encapsulation and sequencing (RAGE‐Seq). It produces antimicrobial susceptibility phenotypes and the genome sequence of 99.5% coverage simultaneously from precisely one bacterial cell. The ability to profile and correlate the microbial metabolic phenome and high‐quality genomes at one‐cell resolution...
The small size and low DNA amount of bacterial cells have hindered establishing phenome–genome links in a precisely indexed, one‐cell‐per‐reaction manner. Here, Raman‐Activated Gravity‐driven single‐cell Encapsulation and Sequencing (RAGE‐Seq) is presented, where individual cells are phenotypically screened via single‐cell Raman spectra (SCRS) in an aquatic, vitality‐preserving environment, then the...
In article number 1905925, Hui‐Hua Li, Fu‐Jian Xu, Jie Du, and co‐workers use a crosslinked heparin polysaccharide nanoparticle to coordinate delivery of vascular endothelial growth factor A/C (VEGF‐A/C) isoforms to improve cardiac function via intravenous injection at a dose ratio of 3:1 (VEGF‐C vs VEGF‐A). Excellent recovery of cardiac function is successfully demonstrated through improving collateral...
Protein‐based therapies are potential treatments for cancer, immunological, and cardiovascular diseases. However, effective delivery systems are needed because of their instability, immunogenicity, and so on. Crosslinked negatively charged heparin polysaccharide nanoparticle (HepNP) is proposed for protein delivery. HepNP can efficiently condense vascular endothelial growth factor (VEGF) because of...
In article number 1901930, Li Zhao, Naoki Komatsu, and co‐workers functionalize nanodiamonds with polyglycerol and cyanine dye, effectively shielding protein adsorption in the blood stream, and prolonging in vivo circulation significantly. As a result, only the tumor is clearly imaged by near‐infrared fluorescence from the nanodiamonds due to their preferential accumulation in tumor rather than the...
Preferential accumulation of nanoparticles in a tumor is realized commonly by combined effects of active and passive targeting. However, passive targeting based on an enhanced permeation and retention (EPR) effect is not sufficient to observe clear tumor fluorescence images in most of the in vivo experiments using tumor‐bearing mice. Herein, polyglycerol‐functionalized nanodiamonds (ND‐PG) conjugated...
Microenvironment‐responsive supramolecular assemblies have attracted great interest in the biomedical field due to their potential applications in controlled drug release. In this study, oxidation‐responsive supramolecular polycationic assemblies named CPAs are prepared for nucleic acid delivery via the host–guest interaction of β‐cyclodextrin based polycations and a ferrocene‐functionalized zinc...
The human society is faced with daunting threats from bacterial infections. Over decades, a variety of antibacterial polymeric nanosystems have exhibited great promise for the eradication of multidrug‐resistant bacteria and persistent biofilms by enhancing bacterial recognition and binding capabilities. In this Review, the “state‐of‐the‐art” biodegradable antibacterial polymeric nanosystems, which...
Flexible energy storage electronics have gained increasing attention in recent years, but the simultaneous acquiring of high volumetric and high areal capacities as well as excellent flexibility in order to truly implement wearable and portable electronics in practice remains challenging. Here, a conductive and highly deformable freestanding all‐pseudocapacitive paper electrode (Ti3C2Tx/MnO2 NWs)...
Nucleic acid‐based therapy specially needs a safe and robust delivery vector. Herein, a novel fluorinated acid‐labile branched hydroxyl‐rich polycation (ARP‐F) is proposed for the flexible and effective delivery nanovector of different plasmids including reporter genes and the Cas9 plasmid. Acid‐responsive polycation (ARP) with plentiful ortho ester linkages and hydroxyl groups is first synthesized...
Sodium‐ion batteries (SIBs) have attracted tremendous interest and become a worldwide research hotpot owing to their low cost and abundant resources. To obtain suitable anode materials with excellent performance for SIBs, an effective and controllable strategy is presented to fabricate SnS2 nanosheets coating on nanohollow cubic CoS2/C (CoS2/C@SnS2) composites with a hollow structure using Co‐metal‐organic...
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