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Plancitoxin I, the major lethal factor from the crown-of-thorns starfish Acanthaster planci venom, is quite unique not only in exhibiting potent hepatotoxicity but also in sharing high sequence homology with mammalian deoxyribonulease II. In this study, morphological and biochemical changes in rat liver epithelial cells (TRL 1215 cells) treated with the toxin were examined to understand the mechanism...
The full-length cDNAs encoding two toxic phospholipases A 2 (AP-PLA 2 -I and -II) from the crown-of-thorns starfish Acanthaster planci venom were individually cloned by RT-PCR, 3′RACE and 5′RACE. In common with both AP-PLA 2 s, the precursor protein is composed of a signal peptide, a propeptide and a mature protein (136 and 135 residues for AP-PLA 2 -I and -II, respectively)...
Two lethal factors (named plancitoxins I and II for major and minor toxins, respectively) with the same LD 50 (i.v. injection into mice) of 140μg/kg were purified from spines of the crown-of-thorns starfish Acanthaster planci. Injection of a sublethal dose of plancitoxin I or II into mice remarkably elevated serum levels of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase,...
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