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Aim
Despite appropriate use of antiemetics including 5‐hydroxytryptamine type 3 (5‐HT3) receptor antagonists, chemotherapy‐induced nausea and vomiting (CINV) is still an unsolved problem in patients with anticancer drugs. We examined whether the variants of ABCB1, CYP2D6 and HTR3B affect efficacy of ramosetron, a selective 5‐HT3 receptor antagonist in a dose escalation clinical trial.
Methods
We...
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