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Background
Experimental autoimmune prostatitis (EAP) and prostatitis induced by 17β‐estradiol treatment combined with castration (hormone/castration‐induced prostatitis; HCP) are the most commonly used rodent models of nonbacterial prostatitis. We studied the effect of the phosphodiesterase 5 inhibitor tadalafil on chronic pelvic pain in two such models in rats.
Methods
EAP was induced by intradermal...
Background
Experimental autoimmune prostatitis (EAP) is most often used as a nonbacterial model of chronic prostatitis/chronic pelvic pain. We investigated the development of chronic pelvic pain and inflammatory changes in rat EAP and examined the effect of a single treatment with phosphodiesterase 5 (PDE5) inhibitors on the chronic pelvic pain.
Methods
EAP was induced in rats by intradermal injection...
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