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The Ink4 locus at chromosome 9p21 encodes P15Ink4b, P14Arf, P16Ink4a, MTAP, ncRNA ANRIL/p15AS and p16AS, which play an important role in regulation of stem cell self-renewal. Loss of functions of these genes promotes cell proliferation through bypassing checkpoint between the G1 and S phase of the cell cycle. Transcriptional...
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