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A high ionization efficiency derivatization reagent with a diazonium moiety, 4-diazomethylpyridine, has been designed for prostaglandins labeling. The labeled prostaglandins are then determined by LC–MS/MS. Prostaglandin E2 (PGE2) in rat brain homogenate was used for evaluation of the analytical potential of this reagent. 4-Diazomethylpyridine was synthesized in three steps. Analytes were purified...
A rapid, sensitive and accurate high performance liquid chromatography method using tandem mass spectrometry detection for hydralazine in BALB/C mouse plasma and brain was developed and validated. The method involved a derivatization with 2,4-pentanedione at 50 °C for 1 h, and a step of solid phase extraction to purify and concentrate hydralazine derivative. Chromatographic separation was carried...
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