Search results for: Alessandro Sannino

Items from 1 to 20 out of 46 results

article

Smooth‐rough asymmetric PLGA structure made of dip coating membrane and electrospun nanofibrous scaffolds meant to be used for guided tissue regeneration of periodontium

Paola Nitti, Barbara Palazzo, Nunzia Gallo, Francesca Scalera, more

Polymer Engineering & Science > 62 > 6 > 2061 - 2069

A surgical procedure for the repair of damaged periodontal tissue is Guided Tissue Regeneration (GTR), which involves the use of a barrier membrane to prevent soft tissue ingrowth and create a space for slow regeneration of periodontium and bone. GTR membrane should have pores able to facilitate the diffusion of fluids, oxygen, nutrients, and bioactive substances for cell growth, but also be impermeable...

article

Semi‐interpenetrating polymer network cryogels based on poly(ethylene glycol) diacrylate and collagen as potential off‐the‐shelf platforms for cancer cell research

Ugo Masullo, Anna Cavallo, Maria Raffaella Greco, Stephan J. Reshkin, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 109 > 9 > 1313 - 1326

In the present work, we investigated the potential of novel semi‐interpenetrating polymer network (semi‐IPN) cryogels, obtained through ultraviolet exposure of aqueous mixtures of poly(ethylene glycol) diacrylate and type I collagen, as tunable off‐the‐shelf platforms for 3D cancer cell research. We synthesized semi‐IPN cryogels with variable collagen amounts (0.1% and 1% w/v) and assessed the effect...

article

Sub‐ and Supramolecular X‐Ray Characterization of Engineered Tissues from Equine Tendon, Bovine Dermis, and Fish Skin Type‐I Collagen

Alberta Terzi, Nunzia Gallo, Simona Bettini, Teresa Sibillano, more

Macromolecular Bioscience > 20 > 5 > n/a - n/a

Collagen represents one of the most widely used biomaterial for scaffolds fabrication in tissue engineering as it represents the mechanical support of natural tissues. It also provides physical scaffolding for cells and it influences their attachment, growth, and tissue regeneration. Among all fibrillary collagens, type I is considered one of the gold standard for scaffolds fabrication, thanks to...

article

Erratum: A Randomized, Double‐Blind, Placebo‐Controlled Study of Gelesis100: A Novel Nonsystemic Oral Hydrogel for Weight Loss

Frank L. Greenway, Louis J. Aronne, Anne Raben, Arne Astrup, more

Obesity > 27 > 7 > 1210 - 1210

article

Biodegradable poly(lactic acid)/cellulose‐based superabsorbent hydrogel composite material as water and fertilizer reservoir in agricultural applications

Paola Calcagnile, Teresa Sibillano, Cinzia Giannini, Alessandro Sannino, more

Journal of Applied Polymer Science > 136 > 21 > n/a - n/a

The work presents a fully degradable superabsorbent composite material to be used in agricultural and horticultural applications. It is designed to retain and release fertilizer solutions to the soil in a controlled manner, permitting resource optimization. Because of its ability to absorb and release large amounts of saline water, a natural superabsorbent hydrogel derived from cellulose was chosen...

article

A Randomized, Double‐Blind, Placebo‐Controlled Study of Gelesis100: A Novel Nonsystemic Oral Hydrogel for Weight Loss

Frank L. Greenway, Louis J. Aronne, Anne Raben, Arne Astrup, more

Obesity > 27 > 2 > 205 - 216

Objective This study aims to assess the efficacy and safety of Gelesis100, a novel, nonsystemic, superabsorbent hydrogel to treat overweight or obesity. Methods The Gelesis Loss Of Weight (GLOW) study was a 24‐week, multicenter, randomized, double‐blind, placebo‐controlled study in patients with BMI ≥ 27 and ≤ 40 kg/m² and fasting plasma glucose ≥ 90 and ≤ 145 mg/dL. The co‐primary end points...

article

Determination of absorption and structural properties of cellulose-based hydrogel via ultrasonic pulse-echo time-of-flight approach

Leonardo Lamanna, Francesco Rizzi, Christian Demitri, Marco Pisanello, more

Cellulose > 2018 > 25 > 8 > 4331-4343

Biodegradable cellulose-based hydrogels are attracting increasing interest in the academic and industrial fields thanks to their high swelling capacity and reproducibility, which allow many novel applications. These properties are enabled by amplification effect of their sensitiveness on a molecular level, translated into macroscopic effects such as a change in swelling degree. The monitoring of the...

article

Effect of inorganic and organic bioactive signals decoration on the biological performance of chitosan scaffolds for bone tissue engineering

Alessandra Soriente, Ines Fasolino, Maria Grazia Raucci, Christian Demitri, more

Journal of Materials Science: Materials in Medicine > 2018 > 29 > 5 > 1-12

The present work is focused on the design of a bioactive chitosan-based scaffold functionalized with organic and inorganic signals to provide the biochemical cues for promoting stem cell osteogenic commitment. The first approach is based on the use of a sequence of 20 amino acids corresponding to a 68–87 sequence in knuckle epitope of BMP-2 that was coupled covalently to the carboxyl group of chitosan...

article

Proteomic expression profile of injured rat peripheral nerves revealed biological networks and processes associated with nerve regeneration

Daniele Vergara, Alessandro Romano, Eleonora Stanca, Velia La Pesa, more

Journal of Cellular Physiology > 233 > 8 > 6207 - 6223

Peripheral nerve regeneration is regulated through the coordinated spatio‐temporal activation of multiple cellular pathways. In this work, an integrated proteomics and bioinformatics approach was employed to identify differentially expressed proteins at the injury‐site of rat sciatic nerve at 20 days after damage. By a label‐free liquid chromatography mass‐spectrometry (LC‐MS/MS) approach, we identified...

article

One-step solvent-free process for the fabrication of high loaded PLA/HA composite filament for 3D printing

Carola Esposito Corcione, Francesca Scalera, Francesca Gervaso, Francesco Montagna, more

Journal of Thermal Analysis and Calorimetry > 2018 > 134 > 1 > 575-582

Calcium phosphate, like hydroxyapatite (HA), is the principal bioactive material for bone grafts substitute, but being ceramics materials, it is not suitable for low-cost 3D printing techniques, such as fused deposition modeling (FDM). To this aim, HA is usually mixed with a 3D-printable thermoplastic polymer, like polylactic acid (PLA), in order to realize customized substitutes by FDM technique...

article

Novel PHB/Olive mill wastewater residue composite based film: Thermal, mechanical and degradation properties

Vito Emanuele Carofiglio, Paolo Stufano, Nadia Cancelli, Vincenzo Maria De Benedictis, more

Journal of Environmental Chemical Engineering > 2017 > 5 > 6 > 6001-6007

In the last few years there has been a growing interest in the use of bio-based and biodegradable plastics, made of renewable resources. A common biodegradable polymer, microbial-derived, is Poly-3-hydroxybutiric acid (PHB). However, PHB homopolymer exhibits a high crystalline structure, which leads to mechanical properties that are not fully compatible with a number of production processes. An interesting...

article

Enhanced electrical conductivity of collagen films through long-range aligned iron oxide nanoparticles

Valentina Bonfrate, Daniela Manno, Antonio Serra, Luca Salvatore, more

Journal of Colloid and Interface Science > 2017 > 501 > C > 185-191

The development of biocompatible collagen substrates able to conduct electric current along specific pathways represent an appealing issue in tissue engineering, since it is well known that electrical stimuli significantly affects important cell behaviour, such as proliferation, differentiation, directional migration, and, therefore, tissue regeneration. In this work, a cheap and easy approach was...

article

Encapsulation of Lactobacillus kefiri in alginate microbeads using a double novel aerosol technique

Christian Demitri, Leonardo Lamanna, Egidio De Benedetto, Fabrizio Damiano, more

Materials Science and Engineering: C > 2017 > 77 > C > 548-555

Alginate micro beads containing Lactobacillus kefiri (the principal bacteria present in the kefir probiotic drink) were produced by a novel technique based on dual aerosols spaying of alginate based solution and CaCl₂ as cross linking agent. Carboxymethylcellulose (CMC) has been also added to the alginate in order to change the physic-chemical properties (viscosity and permeability) of the microbeads...

article

Simplified preparation and characterization of magnetic hydroxyapatite-based nanocomposites

Stefania Scialla, Barbara Palazzo, Amilcare Barca, Luigi Carbone, more

Materials Science and Engineering: C > 2017 > 76 > C > 1166-1174

Authors aimed to provide a magnetic responsiveness to bone-mimicking nano-hydroxyapatite (n-HA). For this purpose, dextran-grafted iron oxide nanoarchitectures (DM) were synthesized by a green-friendly and scalable alkaline co-precipitation method at room temperature and used to functionalize n-HA crystals. Different amounts of DM hybrid structures were added into the nanocomposites (DM/n-HA 1:1,...

article

A novel composite type I collagen scaffold with micropatterned porosity regulates the entrance of phagocytes in a severe model of spinal cord injury

Silvia Snider, Andrea Cavalli, Francesca Colombo, Alberto Luigi Gallotti, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 105 > 5 > 1040 - 1053

Traumatic spinal cord injury (SCI) is a damage to the spinal cord that results in loss or impaired motor and/or sensory function. SCI is a sudden and unexpected event characterized by high morbidity and mortality rate during both acute and chronic stages, and it can be devastating in human, social and economical terms. Despite significant progresses in the clinical management of SCI, there remain...

article

Sterilization of collagen scaffolds designed for peripheral nerve regeneration: Effect on microstructure, degradation and cellular colonization

Graziana Monaco, Rahmatullah Cholas, Luca Salvatore, Marta Madaghiele, more

Materials Science and Engineering: C > 2017 > 71 > C > 335-344

In this study we investigated the impact of three different sterilization methods, dry heat (DHS), ethylene oxide (EtO) and electron beam radiation (β), on the properties of cylindrical collagen scaffolds with longitudinally oriented pore channels, specifically designed for peripheral nerve regeneration. Scanning electron microscopy, mechanical testing, quantification of primary amines, differential...

article

Microwave‐induced porosity and bioactivation of chitosan‐PEGDA scaffolds: morphology, mechanical properties and osteogenic differentiation

Christian Demitri, Antonella Giuri, Vincenzo Maria De Benedictis, Maria Grazia Raucci, more

Journal of Tissue Engineering and Regenerative Medicine > 11 > 1 > 86 - 98

In this study, a new foaming method, based on physical foaming combined with microwave‐induced curing, is proposed in combination with a surface bioactivation to develop scaffold for bone tissue regeneration. In the first step of the process, a stable physical foaming was induced using a surfactant (Pluronic) as blowing agent of a homogeneous blend of Chitosan and polyethylene glycol diacrylate (PEGDA700)...

article

The feasibility of printing polylactic acid–nanohydroxyapatite composites using a low‐cost fused deposition modeling 3D printer

Carola Esposito Corcione, Francesca Gervaso, Francesca Scalera, Francesco Montagna, more

Journal of Applied Polymer Science > 134 > 13 > n/a - n/a

The current “gold standard” to treat bone lesions is allografts and autografts, both presenting important disadvantages such as risk of infection and morbidity. Synthetic grafts and scaffolds for bone regeneration represent a promising solution. Fused deposition modeling is a valid tool for developing synthetic bone grafts of complex shapes, which is a key issue. The possibility of building polylactic...

article

Mechanical stability of highly porous hydroxyapatite scaffolds during different stages of in vitro studies

Francesca Gervaso, Sanosh Kunjalukkal Padmanabhan, Francesca Scalera, Alessandro Sannino, more

Materials Letters > 2016 > 185 > C > 239-242

Degradation properties of bone scaffolds are strongly related to cell growth, host response and tissue regeneration. However, bone formation is a very slow process and, in the first few weeks after implantation, the mechanical stability of the scaffold plays a key role for the success of the regeneration progression. In the present study, in vitro properties of highly porous hydroxyapatite (HA) scaffolds...

article

Efficacy of silver coated surgical sutures on bacterial contamination, cellular response and wound healing

Anna Lucia Gallo, Federica Paladini, Alessandro Romano, Tiziano Verri, more

Materials Science and Engineering: C > 2016 > 69 > C > 884-893

The resistance demonstrated by many microorganisms towards conventional antibiotics has stimulated the interest in alternative antimicrobial agents and in novel approaches for prevention of infections. Silver, a natural braod-spectrum antimicrobial agent known since antiquity, has been widely employed in biomedical field due to its recognized antibacterial, antifungal and antiviral properties. In...

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INFONA - science communication portal

Search results for: Alessandro Sannino

Smooth‐rough asymmetric PLGA structure made of dip coating membrane and electrospun nanofibrous scaffolds meant to be used for guided tissue regeneration of periodontium

Semi‐interpenetrating polymer network cryogels based on poly(ethylene glycol) diacrylate and collagen as potential off‐the‐shelf platforms for cancer cell research

Sub‐ and Supramolecular X‐Ray Characterization of Engineered Tissues from Equine Tendon, Bovine Dermis, and Fish Skin Type‐I Collagen

Erratum: A Randomized, Double‐Blind, Placebo‐Controlled Study of Gelesis100: A Novel Nonsystemic Oral Hydrogel for Weight Loss

Biodegradable poly(lactic acid)/cellulose‐based superabsorbent hydrogel composite material as water and fertilizer reservoir in agricultural applications

A Randomized, Double‐Blind, Placebo‐Controlled Study of Gelesis100: A Novel Nonsystemic Oral Hydrogel for Weight Loss

Determination of absorption and structural properties of cellulose-based hydrogel via ultrasonic pulse-echo time-of-flight approach

Effect of inorganic and organic bioactive signals decoration on the biological performance of chitosan scaffolds for bone tissue engineering

Proteomic expression profile of injured rat peripheral nerves revealed biological networks and processes associated with nerve regeneration

One-step solvent-free process for the fabrication of high loaded PLA/HA composite filament for 3D printing

Novel PHB/Olive mill wastewater residue composite based film: Thermal, mechanical and degradation properties

Enhanced electrical conductivity of collagen films through long-range aligned iron oxide nanoparticles

Encapsulation of Lactobacillus kefiri in alginate microbeads using a double novel aerosol technique

Simplified preparation and characterization of magnetic hydroxyapatite-based nanocomposites

A novel composite type I collagen scaffold with micropatterned porosity regulates the entrance of phagocytes in a severe model of spinal cord injury

Sterilization of collagen scaffolds designed for peripheral nerve regeneration: Effect on microstructure, degradation and cellular colonization

Microwave‐induced porosity and bioactivation of chitosan‐PEGDA scaffolds: morphology, mechanical properties and osteogenic differentiation

The feasibility of printing polylactic acid–nanohydroxyapatite composites using a low‐cost fused deposition modeling 3D printer

Mechanical stability of highly porous hydroxyapatite scaffolds during different stages of in vitro studies

Efficacy of silver coated surgical sutures on bacterial contamination, cellular response and wound healing

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