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ABSTRACT
BACKGROUND AND PURPOSETo determine the proper method for the normalization of spinal cord volume.
MATERIALS AND METHODSA group of 34 multiple sclerosis (MS) patients (28 relapsing and 6 progressive) and 15 healthy controls had whole spinal cord 3‐mm thick T2‐weighted axial fast spin‐echo magnetic resonance imaging (MRI) images obtained at 3T. For each participant, four volumes were measured (C2‐3 volume, cervical cord volume, thoracic cord volume, and whole cord volume). The volumes were normalized by the number of slices and three potential measures of body size (intracranial volume [ICV], body mass index, and body surface area) using the proportional method....
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