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One method by which to modify the release rate of a drug in the pulmonary tract, is through the use of polymeric systems. There are several natural and synthetic polymers that have been studied in vitro or in vivo in animals to assess pulmonary drug delivery and sustained release. This chapter focuses on some of the more common non-conjugated polymers utilized for inhalation drug delivery and draws...
Experimentally, there are a plethora of excipients used for pulmonary-administered agents and formulations. However, far fewer have been tested in humans. The limited use of excipients is indicative of the difficulty of selecting an excipient that will not limit aerosolization performance, is safe with little-to-no immunogenicity, and is effective in sustaining drug release. These issues and topics...
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