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Diphtheria toxoid (DT) was encapsulated in microparticles prepared from polylactideco-glycolide (PLG) polymers using a solvent evaporation technique. Combinations of small and large sized microparticles with controlled release characteristics were used to immunize Sprague Dawley rats and the antibody responses were monitored for one year. For comparison, control groups of rats were immunized at...
Hepatitis B surface antigen (HBsAg) was encapsulated in microparticles prepared from polyactide-co-glycolide (PLG) and polylactide (PLA) polymers using a solvent evaporation process. The immunoreactivity of the entrapped antigen was investigated by SDS-PAGE and Western blot. The microencapsulation process was modified to obtain both small (<10 μm) and large microparticles (10-100< μm), 80%...
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