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Using a combination of structural and mechanical characterization, we examine the effect of fibrinogen oxidation on the formation of fibrin clots. We find that treatment with hypochlorous acid preferentially oxidizes specific methionine residues on the α, β, and γ chains of fibrinogen. Oxidation is associated with the formation of a dense network of thin fibers after activation by thrombin. Additionally,...
Formation of heteromeric complexes between voltage-gated K+ (Kv) channels and accessory (β) subunits is a widespread means to generate heterogeneity of K+ current in the nervous system. Here we investigate the principles that determine the interactions of Caenorhabditis elegans MPS-1, a bifunctional β-subunit that possesses kinase activity, with Kv channels. MPS-1 belongs to the evolutionarily conserved...
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