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Infections with multidrug‐resistant (MDR) pathogens are increasingly concerning for public health. Synthesized antimicrobial peptide A4 (SAMP‐A4), a peptide computationally designed by our research team, is a potential drug candidate. However, the antimicrobial peptide SAMP‐A4 is easily degraded in serum. To obtain SAMP‐A4 analogues with high biostability, chemical modifications at its N‐terminus,...
Antimicrobial peptide L163 was computationally designed by our laboratory; L163 is active against multidrug‐resistant (MDR) bacteria but is easily degraded in the plasma and by trypsin. Amino acid substitution, cyclization, and amino‐terminal (N‐terminal) acetylation were performed to obtain L163 analogs with high stability in the plasma and in trypsin solutions. The stability, antimicrobial activity,...