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Benzo(a)pyrene‐7,8‐dihydrodiol‐9,10‐epoxide (BPDE), the metabolite of environmental pollutant benzo(a)pyrene (B(a)P) could induce pulmonary toxicity and inflammation. SIRT1, an NAD+ ‐dependent histone deacetylase, is known to regulate inflammation in the occurrence and development of various diseases, but its effects on BPDE‐induced acute lung injury are still unknown. The present study aimed to explore...
Benzo(a)pyrene(B(a)P), as the main representative of polycyclic aromatic hydrocarbons, can promote inflammation and many chronic pulmonary diseases. However, the underlying mechanism of Benzo(a)pyrene‐7,8‐diol‐9,10‐epoxide (BPDE)‐induced human bronchial epithelial cell pyroptosis related to endoplasmic reticulum stress (ERS) has not been elucidated. This study focused on the effects of BPDE on ERS...