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The cardiomyocyte differentiation from mouse embryonic stem cells (mESCs) is a dynamic and complex process that involved in the precision regulation of histone acetylation. The formation of action potential (AP) in mature cardiomyocytes is based on the expression pattern of Na+, Ca2+, and K+ ion channels, in which the slow delayed rectifier potassium current (IKs), the rapid delayed rectifier potassium...
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