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In this chapter we briefly summarize the use of echinostomes in chemotherapeutic studies and provide a comprehensive overview of metabolic profiling using an Echinostoma caproni-mouse model. In vitro and in vivo assays with Echinostoma spp. are suitable means for screening of anthelminthic drugs. Indeed, these models have been utilized for more than three decades and play an important role for discovery...
In 2009, for the first time in history, more people were found to live in urban areas than in rural settings. Predictions for 2025 are that 70% of the world’s population will be urban. Urban dwellers in particular, then, will need to adapt to climate change. Urbanization occurs at a rapid pace in secondary cities across Africa. Indeed, half the increase of urban populations in the coming years is...
This chapter contains sections titled:
Schistosomiasis: a Neglected Tropical Disease and the Need for New Drugs
What's Old is New Again: Analogs of PZQ
Alternatives to PZQ – Aminoethanethiosulfuric Acids
Alternatives to PZQ: the Artemisinins and Synthetic Trioxolanes
Validated Protein Targets for Possible New Therapies
Semi‐Automated Medium‐Throughput Phenotypic Screening
Conclusions
Acknowledgments...
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