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Prolonged hemorrhagic shock and subsequent resuscitation frequently results in hemodynamic compromise. This study was designed to investigate the hemodynamic effect of the stepwise increase of blood pressure during initial resuscitation.Fifteen anesthetized male pigs (35 ± 5 kg) were used. Hemorrhagic shock was induced by losing 40% of estimated blood volume over 40 min and 10% of estimated blood...
N-acetylcysteine (NAC) has been investigated to attenuate organ injury in various experimental and clinical studies. However, results in hemorrhagic shock (HS) were controversial. We determined the effects of continuous administration of NAC on acute lung injury (ALI) and acute kidney injury (AKI) in HS model.Twenty male Sprague-Dawley rats were used. Pressure controlled HS model defined by mean arterial...
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