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Previous studies have demonstrated that circulating DNA-encapsulated microbubbles (MBs) combined with focused ultrasound (FUS) can be used for local blood-brain barrier (BBB) opening and gene delivery. However, few studies focused on how to increase the efficiency of gene delivery to brain tumors after the released gene penetrating the BBB. Here, we proposed the use of folate-conjugated DNA-loaded...
The major obstacles that limit the success of delivery chemotherapeutic substances in brain tumors is their ability to reach the lesion at necessary doses while minimizing deposition at healthy locations to reduce nonspecific toxicity. Lately, administration of therapeutic substances after blood-brain barrier disruption (BBBD) by microbubbles (MBs) with focused ultrasound (FUS) has been demonstrated...
Focused ultrasound (FUS) with microbubbles (MBs) has been confirmed to achieve the blood-brain barrier disruption (BBBD). Magnetic resonance imaging (MRI) can monitor the contrast agent leakage such as superparamagnetic iron oxide (SPIO) after BBBD, which relies on indirect drug-contrast agent relationship and fails to perform direct drug quantification/distribution monitoring. This study proposed...
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