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Key points
Changes in haematocrit influence nitric oxide signalling through alterations in shear stress stimuli and haemoglobin scavenging of nitric oxide; these two regulatory factors have not been assessed simultaneously
Isovolumic haemodilution led to a marked increase in brachial artery flow‐mediated dilatation in humans
The increase in flow‐mediated dilatation occurred in the face of an unaltered...
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